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SB357134

CAT: 0804-HY-119061Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119061Size:1 Each
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Description
SB-357134 is a potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist. SB-357134 enhances memory and learning and increases seizure threshold in rats[1].
CAS Number
219963-52-7
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb357134.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C(N2CCNCC2)=C1)OC)(NC3=CC(Br)=CC(F)=C3Br)=O
Molecular Formula
C17H18Br2FN3O3S
Molecular Weight
523.21
References & Citations
[1]Stean TO, et al. Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT (6) receptor antagonist. Pharmacol Biochem Behav. 2002 Apr;71 (4) :645-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor

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CatalogName
T28689-01SB357134

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