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VU0361747

CAT: 0804-HY-118022Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118022Size:1 Each
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Description
VU0361747 is a potent and selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM) . VU0361737 has neuroprotective effect. VU0361737 significantly reverses Amphetamine-induced hyperlocomotion in vivo[1].
CAS Number
1309976-66-6
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0361747.html
Solubility
10 mM in DMSO
Smiles
OC1CCN(CC1)C(C2=CC=C(N=C2)C#CC3=CC=CC(F)=C3)=O
Molecular Formula
C19H17FN2O2
Molecular Weight
324.35
References & Citations
[1]Noetzel, et al. Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function. Molecular Pharmacology, 81 (2), 120–133.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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