Products for Research Use Only
RegisterLogin

Evogliptin

CAT: 0804-HY-117985Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-117985Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation[1][2][3][4].
CAS Number
1222102-29-5
Product Name Alternative
DA-1229
UNSPSC
12352005
Target
Autophagy; Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/evogliptin.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCN(C(C[C@H](N)CC2=CC(F)=C(F)C=C2F)=O)[C@@H]1COC(C)(C)C
Molecular Formula
C19H26F3N3O3
Molecular Weight
401.42
References & Citations
[1]Yoon H, et al. Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells. Biomol Ther (Seoul) . 2021 Mar 1;29 (2) :154-165. |[2]Seo H Y, et al. Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells. International Journal of Molecular Sciences, 2022, 23 (19) : 11636. |[3]Kim TH, et al. Hepatic role in an early glucose-lowering effect by a novel dipeptidyl peptidase 4 inhibitor, evogliptin, in a rodent model of type 2 diabetes. Eur J Pharmacol. 2016 Jan 15;771:65-76. |[4]Tan X, et al. Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2016 Jun;17 (9) :1285-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

Alternative Products

CatalogName
sc-507284Evogliptin
T31732-01Evogliptin HCl
FE182609-01Evogliptin tartrate
CS-O-39279Evogliptin D4
TRC-D154892-25MGEvogliptin-d9
AR-E02261-01Evogliptin Impurity 1
AR-E02259-01Evogliptin Tartrate Impurity S1
AR-E10891-01Evogliptin-d4 Tartrate
AR-E10890-01Evogliptin Tartrate Impurity S3
AR-E10889-01Evogliptin Tartrate Impurity S2

Popular Products