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Alphadolone

CAT: 0804-HY-117979-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117979-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alphadolone is a GABAA receptor positive allosteric modulator. Alphadolone has antinociceptive effects. Alphadolone causes general anaesthesia[1][2].
CAS Number
14107-37-0
Product Name Alternative
Alfadolone
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alphadolone.html
Solubility
10 mM in DMSO
Smiles
C[C@]1([C@H](CC[C@]1([C@@]2(CC[C@]3(C[C@@H](CC[C@@]3([C@]24[H])C)O)[H])[H])[H])C(CO)=O)CC4=O
Molecular Formula
C21H32O4
Molecular Weight
348.48
References & Citations
[1]Halsey MJ, et al. Pressure reversal of alphaxalone/alphadolone and methohexitone in tadpoles: evidence for different molecular sites for general anaesthesia. Br J Pharmacol. 1986 Oct;89 (2) :299-305.|[2]Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA (A) receptors. Pain. 2000 Oct;88 (1) :31-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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