Alphadolone

• Description :

  Alphadolone is a GABAA receptor positive allosteric modulator. Alphadolone has antinociceptive effects. Alphadolone causes general anaesthesia[1][2].

• Product Name Alternative :

  Alfadolone

• UNSPSC :

  12352211

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/alphadolone.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]1([C@H](CC[C@]1([C@@]2(CC[C@]3(C[C@@H](CC[C@@]3([C@]24[H])C)O)[H])[H])[H])C(CO)=O)CC4=O

• Molecular Formula :

  C21H32O4

• Molecular Weight :

  348.48

• References & Citations :

  [1]Halsey MJ, et al. Pressure reversal of alphaxalone/alphadolone and methohexitone in tadpoles: evidence for different molecular sites for general anaesthesia. Br J Pharmacol. 1986 Oct;89 (2) :299-305.|[2]Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA (A) receptors. Pain. 2000 Oct;88 (1) :31-39.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [14107-37-0]