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RB-6145

CAT: 0804-HY-117630Size: 1 EachDry Ice: NoHazardous: No
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Description
RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
CAS Number
129448-97-1
UNSPSC
12352005
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rb-6145.html
Solubility
10 mM in DMSO
Smiles
OC(CNCCBr)CN1C=CN=C1[N+]([O-])=O.Br
Molecular Formula
C8H14Br2N4O3
Molecular Weight
374.03
References & Citations
[1]S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21 (2) :387-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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