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Meclofenamic acid

CAT: 0804-HY-117275-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117275-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m (6) A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].
CAS Number
644-62-2
Product Name Alternative
Meclofenamate
UNSPSC
12352005
Hazard Statement
H301
Target
Endogenous Metabolite; Fat Mass and Obesity-associated Protein (FTO) ; Gap Junction Protein; Potassium Channel
Type
Reference compound
Related Pathways
Cytoskeleton; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/meclofenamic-acid.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 7.14 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl
Molecular Formula
C14H11Cl2NO2
Molecular Weight
296.15
Precautions
H301
References & Citations
[1]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.|[2]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.|[3]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43 (1) :373-84.|[4]Lee YT, et al. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol. 1999 Aug 13;378 (3) :349-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Biomed Opt Express. 2021 Mar 9;12 (4) :1962-1973.|SSRN. 2025 Jan 27.|Biomater Adv. 2023 Nov:154:213634.|Cancer Commun (Lond) . 2025 May;45 (5) :608-631.|PLoS Pathog. 2025 Jan 21;21 (1) :e1012895.|Sensor Actuat B-Chem. 2021, 129983.|Theranostics. 2021 Jul 25;11 (17) :8464-8479.

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