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LY243246

CAT: 0804-HY-117058Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117058Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY243246 ((6S) -DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase) . 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis[1].
CAS Number
106400-18-4
Product Name Alternative
(6S) -DDATHF
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ly243246.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O
Molecular Formula
C21H25N5O6
Molecular Weight
443.45
References & Citations
[1]Moran RG, et al. The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. J Biol Chem. 1989;264 (35) :21047-21051.|[2]Lehman NL. The stereospecific cytotoxic potency of (6R) and (6S) -5,10- dideazatetrahydrofolate correlates with cellular folylpolyglutamate synthetase levels. Biochimie. 1995;77 (4) :273-278.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T27933-01LY243246

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