TASP0433864

CAT: 0804-HY-116855Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-116855Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TASP0433864 is a selective positive allosteric modulator (PAM) of metabotropic glutamate 2 (mGlu2) receptor with EC50 values of 199 nM and 206 nM against human and rat mGlu2 receptors, respectively. TASP0433864 has antipsychotic activity[1].

CAS Number

1431980-60-7

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tasp0433864.html

Purity

99.9

Solubility

DMSO : 32.94 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C(C)N2C(O[C@H](COC3=CC=C(C(C)(C)C)C=C3)C2)=N1)N

Molecular Formula

C18H23N3O3

Molecular Weight

329.39

References & Citations

[1]Hiyoshi T, et al. Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J Pharmacol Exp Ther. 2014 Dec;351 (3) :642-53.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR2

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