Propiverine

• Description :

  Propiverine is a potent antimuscarinic agent. Propiverine inhibits cellular calcium influx, thereby diminishing muscle spasm. Propiverine has neurotropic and musculotropic effects on the urinary bladder smooth muscle. Propiverine can used for overactive bladder (OAB) research[1][2].

• CAS Number :

  [60569-19-9]

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/propiverine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)OCCC)OC3CCN(CC3)C

• Molecular Formula :

  C23H29NO3

• Molecular Weight :

  367.48

• References & Citations :

  [1]McKeage K. Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms. Clin Drug Investig. 2013 Jan;33 (1) :71-91.|[2]Madersbacher H, Mürtz G. Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic) . World J Urol. 2001 Nov;19 (5) :324-35.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched