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ML299

CAT: 0804-HY-116273-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-116273-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively) . ML299 decreases invasive migration in U87-MG glioblastoma cells[1].
CAS Number
[1426916-00-8]
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml299.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)Br)N[C@H](CN2CCC3(N(CNC3=O)C4=CC=CC(F)=C4)CC2)C
Molecular Formula
C23H26BrFN4O2
Molecular Weight
489.38
References & Citations
[1]O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56 (6) :2695-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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