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AZA197

CAT: 0804-HY-116269Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116269Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts. AZA197 can be used for the study of colon cancer[1].
CAS Number
1249398-09-1
UNSPSC
12352005
Target
Apoptosis; ERK; PAK; Ras
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aza197.html
Purity
98.71
Solubility
DMSO : 4.5 mg/mL (ultrasonic; warming)
Smiles
CC1=NC(NC(CCCN(CC)CC)C)=NC(NCCC2=CNC3=C2C=CC=C3)=C1
Molecular Formula
C24H36N6
Molecular Weight
408.58
References & Citations
[1]Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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