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7-Hydroxycoumarinyl arachidonate

CAT: 0804-HY-116141-01Size: 5 mg (55.73 mM x 200 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-116141-01Size:5 mg (55.73 mM x 200 μL in Ethanol)
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Description
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].
CAS Number
161180-11-6
Product Name Alternative
7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAGL; Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/7-hydroxycoumarinyl-arachidonate.html
Concentration
55.73 mM * 400 μL in Ethanol
Purity
99.19
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC1=CC=C2C=CC(OC2=C1)=O)=O
Molecular Formula
C29H36O4
Molecular Weight
448.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuren Wang, et al. A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. Assay Drug Dev Technol. 2008 Jun;6 (3) :387-93.|[2]Z Huang, et al. A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. Anal Biochem. 1994 Oct;222 (1) :110-5.|[3]R T Pickard, et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996 Aug 9;271 (32) :19225-31.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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