Products for Research Use Only
RegisterLogin

Ap44mSe

CAT: 0804-HY-115832Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-115832Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].
CAS Number
79514-49-1
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ap44mse.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=NC=CC=C1)=N\NC(N(C)C)=[Se]
Molecular Formula
C10H14N4Se
Molecular Weight
269.20
References & Citations
[1]Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe) : Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59 (1) :294-312.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS5776367Ap44mSe

Popular Products