FF-10502

• Description :

  FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ff-10502.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N([C@@H]2S[C@H](CO)[C@@H](O)[C@@H]2F)C=CC(N)=N1

• Molecular Formula :

  C9H12FN3O3S

• Molecular Weight :

  261.27

• References & Citations :

  [1]Shinji Mima, et al. FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells. J Pharmacol Exp Ther. 2018 Jul;366 (1) :125-135.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [184302-49-6]