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Piericidin A

CAT: 0804-HY-114936-01Size: 1 mg (12.03 mM x 200 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-114936-01Size:1 mg (12.03 mM x 200 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca) . Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity[1][2][2].
CAS Number
2738-64-9
Product Name Alternative
AR-054
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
ADC Payload; Antibiotic; Bacterial; Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/piericidin-a.html
Concentration
12.03 mM * 200 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O
Molecular Formula
C25H37NO4
Molecular Weight
415.57
Precautions
H315, H319, H335
References & Citations
[1]Matthias Höllerhage, et al. Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice. PLoS One. 2014 Dec 1;9 (12) :e113557.|[2]Ji Eun Kang, et al. Efficacies of Quorum Sensing Inhibitors, Piericidin A and Glucopiericidin A, Produced by Streptomyces Xanthocidicus KPP01532 for the Control of Potato Soft Rot Caused by Erwinia Carotovora Subsp. Atroseptica. Microbiol Res. 2016 Mar;184:32-41.|[3]Solange Muhayimana, et al. Cytotoxic Selectivity and Apoptosis Induction of Piericidin A Contributes Potentially to Its Insecticidal Effect Against Mythimna Separata (Lepidoptera: Noctuidae) Larvae. Pestic Biochem Physiol. 2019 Jun;157:19-25.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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