Eritadenine

• Description :

  Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma[1][2].

• Product Name Alternative :

  Lentinacin; D-Eritadenine; Lentysine

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Nucleoside Antimetabolite/Analog; Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/eritadenine.html

• Purity :

  97.9

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O

• Molecular Formula :

  C9H11N5O4

• Molecular Weight :

  253.21

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277 (9) :7477-82. |[2]Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S) -DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126 (2) :113-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [23918-98-1]