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KNK423

CAT: 0804-HY-114664-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114664-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
CAS Number
1859-42-3
UNSPSC
12352005
Hazard Statement
H315-H319
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/knk423.html
Solubility
10 mM in DMSO
Smiles
O=C1NCC/C1=C\C2=CC=C3OCOC3=C2
Molecular Formula
C12H11NO3
Molecular Weight
217.22
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7 (1) :215-9.|[2]Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59 (7) :3778-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Heat Shock Protein Inhibitor II
CAS Number1859-42-3
PubChem CID12557979
IUPAC Name(3E)-3-(1,3-benzodioxol-5-ylmethylidene)pyrrolidin-2-one
Molecular FormulaC12H11NO3
Molecular Weight217.22
XLogP1.5
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity326
SMILES
C\1CNC(=O)/C1=C/C2=CC3=C(C=C2)OCO3
InChI
InChI=1S/C12H11NO3/c14-12-9(3-4-13-12)5-8-1-2-10-11(6-8)16-7-15-10/h1-2,5-6H,3-4,7H2,(H,13,14)/b9-5+
InChIKey
IJPPHWXYOJXQMV-WEVVVXLNSA-N
Chemical Structure
2D Structure
2D structure of Heat Shock Protein Inhibitor II
CAS: 1859-42-3
CID: 12557979
Formula: C12H11NO3
MW: 217.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight217.22
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass217.07389321
Monoisotopic Mass217.07389321
Topological Polar Surface Area47.6 Ų
Heavy Atom Count16
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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