Mesoxalate

• UNSPSC Description:

  Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2].

• Target Antigen:

  HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  infection

• Assay Protocol:

  https://www.medchemexpress.com/ketomalonic-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(C(O)=O)=O)O

• Molecular Weight:

  118.04

• References & Citations:

  [1]Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84.|[2]W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  473-90-5