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SGL5213

CAT: 0804-HY-114308Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114308Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. SGL5213 has potential to treat type 2 diabetes treatment[1].
CAS Number
1240305-17-2
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sgl5213.html
Solubility
10 mM in DMSO
Smiles
COC1=C([C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)C=C(CC3=CC=C(/C=C/C(C)(C)C(NC(C)(C)C(NCCN(C)C)=O)=O)C=C3)C(C(C)C)=C1
Molecular Formula
C37H55N3O8
Molecular Weight
669.85
References & Citations
[1]Kuroda S, et al. Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment. Bioorg Med Chem. 2019 Jan 15;27 (2) :394-409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT1

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