7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

• CAS Number: 61563-24-4
• UNSPSC Description: 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/7-8-dichloro-1-2-3-4-tetrahydroisoquinoline.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=C(Cl)C=CC2=C1CNCC2
• Molecular Weight: 202.08
• References & Citations: [1]Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68.|[2]N Y Liang, et al. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. J Pharmacol Exp Ther. 1982 Nov;223(2):382-7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported