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GSK1614343

CAT: 0804-HY-113906Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113906Size:1 Each
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Description
GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC50 value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models[1].
CAS Number
1092076-04-4
UNSPSC
12352005
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gsk1614343.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@@H](C1=CC=CN=C1)N2C[C@@]3([H])CCCN3CC2)NNC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Molecular Formula
C22H23F6N5O
Molecular Weight
487.44
References & Citations
[1]Perdonà E, et al. Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. Eur J Pharmacol. 2011;650 (1) :178-183.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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