ZK112993

CAT: 0804-HY-113889Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-113889Size:1 Each

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Description

ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].

CAS Number

105114-63-4

UNSPSC

12352005

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zk112993.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@@]2(O)C#CC)([H])[C@@]3([H])C([C@@H](C4=CC=C(C=C4)C(C)=O)C1)=C5C(CC3)=CC(CC5)=O

Molecular Formula

C29H32O3

Molecular Weight

428.56

References & Citations

[1]C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268 (13) :9262-6.|[2]Claudia Lanari, et al. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19 (3) :R35-50.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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