Colistin

• UNSPSC Description:

  Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/colistin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [Colistin]

• Molecular Weight:

  1169.50

• References & Citations:

  [1]Silpak Biswas, et al. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012 Aug;10(8):917-34. |[2]Jian Li, et al. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. |[3]Michael T Eadon, et al. Cell cycle arrest in a model of colistin nephrotoxicity. Physiol Genomics. 2013 Oct 1;45(19):877-88.Animal Diseases. 2024 Apr 3.|Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.|Microorganisms. 2024 Mar 13, 12(3), 575.|Vet Microbiol. 2024 May, 292, 110046.|Adv Sci (Weinh). 2020 Jul 21;7(17):2001374.|Animal Diseases. 02 November 2021.|Clin Microbiol Infect. 2020 Sep;26(9):1264-1265.|Hum Exp Toxicol. 2021 Apr 22;9603271211010906.|J Antibiot (Tokyo). 2019 Aug;72(8):600-604. |Nat Commun. 2022 Mar 2;13(1):1116.|Nat Commun. 2024 Sep 10;15(1):7914.|Patent. US20200101105A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  1066-17-7