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A-933548

CAT: 0804-HY-113639Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113639Size:1 Each
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Description
A-933548 is a potent and selective inhibitor of calpain, with a Ki of 18 nM. A-933548 can be used for the research of Alzheimer's disease[1].
CAS Number
1037826-43-9
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-933548.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=CC=C3)NC(CC4=CC=CC=C4)C(C(N)=O)=O
Molecular Formula
C25H21N5O3
Molecular Weight
439.47
References & Citations
[1]Kling A, et, al. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2- (3-Phenyl-1H-pyrazol-1-yl) -nicotinamides. J Med Chem. 2017 Aug 24;60 (16) :7123-7138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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