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Zymostenol

CAT: 0804-HY-113345Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113345Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM) [1][2][3].
CAS Number
566-97-2
Product Name Alternative
5a-Cholest-8-en-3b-ol
UNSPSC
12352211
Target
Endogenous Metabolite; ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zymostenol.html
Purity
99.33
Solubility
DMF : 3 mg/mL (ultrasonic; warming)
Smiles
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Molecular Formula
C27H46O
Molecular Weight
386.65
References & Citations
[1]Hu X, et al. Sterol metabolism controls T (H) 17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11 (2) :141-7. |[2]Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560 (7718) :372-376. |[3]Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7 (12) :3707-18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; RORγ

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