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Etiocholanolone-d5

CAT: 0804-HY-113320SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113320SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etiocholanolone-d5 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator? (PAM) of the GABAA?receptor than its?enantiomer form[2].
CAS Number
1620102-33-1
Product Name Alternative
5β-Androsterone-d5
UNSPSC
12352211
Target
Endogenous Metabolite; GABA Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Purity
99.20
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])C2)([2H])O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
Molecular Formula
C19H25D5O2
Molecular Weight
295.47
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ping Li, et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71 (6) :1582-90.|[3]Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl) . 2014 Sep;231 (17) :3325-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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