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2-Phosphoglyceric acid

CAT: 0804-HY-113167Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113167Size:1 Each
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Description
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP) . 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].
CAS Number
2553-59-5
Product Name Alternative
DL-2-phosphoglyceric acid
UNSPSC
12352211
Hazard Statement
H302-H312-H332
Target
Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-phosphoglyceric-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(OP(O)(O)=O)CO
Molecular Formula
C3H7O7P
Molecular Weight
186.06
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Ramos A, et al. Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis. Appl Environ Microbiol. 2001 Jan;67 (1) :33-41.|[2]Chen H, et al. Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation. Eur J Pharmacol. 2024 May 15;971:176539. |[3]Huang CK, et al. ENO1 and Cancer. Mol Ther Oncolytics. 2022 Jan 3;24:288-298.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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