2-Phosphoglyceric acid

• Description:

  2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP) . 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].

• Product Name Alternative:

  DL-2-phosphoglyceric acid

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H312-H332

• Target:

  Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-phosphoglyceric-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C(OP(O)(O)=O)CO

• Molecular Formula:

  C3H7O7P

• Molecular Weight:

  186.06

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations:

  [1]Ramos A, et al. Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis. Appl Environ Microbiol. 2001 Jan;67 (1) :33-41.|[2]Chen H, et al. Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation. Eur J Pharmacol. 2024 May 15;971:176539. |[3]Huang CK, et al. ENO1 and Cancer. Mol Ther Oncolytics. 2022 Jan 3;24:288-298.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [2553-59-5]