RTS-V5

• UNSPSC Description:

  RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively.

• Target Antigen:

  HDAC; Proteasome

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/RTS-V5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NO)C1=CC=C(C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC2=CC=CC=C2)=O)=O)=O)C=C1

• Molecular Weight:

  525.60

• References & Citations:

  [1]Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61(22):10299-10309.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2285346-31-6