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Darunavir-d9

CAT: 0804-HY-112585Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112585Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Darunavir-d9 (TMC114-d9) is the deuterium labeled Darunavir. Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity[1][2].
CAS Number
1133378-37-6
Product Name Alternative
TMC114-d9; UIC-94017-d9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HIV; HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C27H28D9N3O7S
Molecular Weight
556.72
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Dominique L N G Surleraux, et al. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem. 2005 Mar 24;48 (6) :1813-22.; Yasuhiro Koh, et al. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 2003 Oct;47 (10) :3123-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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