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Menaquinone-7-d7

CAT: 0804-HY-112499SSize: 250 µgDry Ice: NoHazardous: No
CAT#:0804-HY-112499SSize:250 µg
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Description
Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) [3].
CAS Number
[1233937-31-9]
Product Name Alternative
Vitamin K2-7-d7; Vitamin K2 (35) -d7; Vitamin MK-7-d7
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C1C2=C([2H])C([2H])=C([2H])C([2H])=C2C(C(C([2H])([2H])[2H])=C1C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O
Molecular Formula
C46H57D7O2
Molecular Weight
656.04
Precautions
P261-P280-P338-P340-P351-P352
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Thijssen, H H., et al., 1994. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. The British journal of nutrition. 72 (3) : 415-25.|[3]Conly, J M., et al., 1994. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. The American journal of gastroenterology. 89 (6) : 915-23.|[4]Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10 (4) . pii: E386.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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