Menaquinone-7-d7

• Description:

  Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) [3].

• Product Name Alternative:

  Vitamin K2-7-d7; Vitamin K2 (35) -d7; Vitamin MK-7-d7

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others

• Field of Research:

  Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C([2H])C([2H])=C([2H])C([2H])=C2C(C(C([2H])([2H])[2H])=C1C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O

• Molecular Formula:

  C46H57D7O2

• Molecular Weight:

  656.04

• Precautions:

  P261-P280-P338-P340-P351-P352

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Thijssen, H H., et al., 1994. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. The British journal of nutrition. 72 (3) : 415-25.|[3]Conly, J M., et al., 1994. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. The American journal of gastroenterology. 89 (6) : 915-23.|[4]Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10 (4) . pii: E386.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1233937-31-9]