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DS88790512

CAT: 0804-HY-112298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112298Size:1 Each
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Description
DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM.
CAS Number
2231089-95-3
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/DS88790512.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@](C[C@@H](N3C[C@H](N)CCC3)[C@@H]2OC4=CC=C(C#N)C=C4)([H])CC(CC1)=O
Molecular Formula
C22H29N3O2
Molecular Weight
367.48
References & Citations
[1]Motoyama K, et al. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6) . Bioorg Med Chem Lett. 2018 Jul 1;28 (12) :2222-2227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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