(-) -Ibuprofenamide

• Description :

  (-) -Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].

• CAS Number :

  [121839-78-9]

• Product Name Alternative :

  (R) -Ibuprofenamide

• UNSPSC :

  12352005

• Target :

  COX

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ibuprofenamide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)CC1=CC=C([C@@H](C)C(N)=O)C=C1

• Molecular Formula :

  C13H19NO

• Molecular Weight :

  205.30

• References & Citations :

  [1]Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81 (2) :149-54.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported