Products for Research Use Only
RegisterLogin

CD12681

CAT: 0804-HY-111366Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-111366Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis[1].
CAS Number
1952239-59-6
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cd12681.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(NC(N2CC3CCOCC3)=O)=C2C=C1)(N(C4=CC=C(C)C=C4C)CC(C)C)=O
Molecular Formula
C25H33N3O4S
Molecular Weight
471.61
References & Citations
[1]Ouvry G, et al. Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis. ChemMedChem. 2018 Feb 20;13 (4) :321-337.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

Related Products

CatalogName
HY-124596CD161
HY-P84969CD161 Antibody (YA4661)
HY-P80966-01CD161 Antibody (YA853, Mouse)
HY-P83858-01CD168 Antibody (YA3555, Mouse)
HY-P77592-01CD161, Cynomolgus (HEK293, His)
HY-P81577CD168 Antibody (YA1322, Rabbit)
HY-P72750-01CD161, Human (HEK293, Fc)
HY-P78085-01CD161, Human (Biotinylated, HEK293, His-Avi)
HY-P77593CD161, Cynomolgus (Biotinylated, HEK293, His-Avi)

Alternative Products

CatalogName
CDD23959-01CD12681

Popular Products