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CHIC35

CAT: 0804-HY-111303Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111303Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM) . CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM) [1]. CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research[1][2].
CAS Number
848193-72-6
UNSPSC
12352005
Hazard Statement
H301-H315-H319-H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chic35.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1CCCCC2=C1NC3=C2C=C(Cl)C=C3)N
Molecular Formula
C14H15ClN2O
Molecular Weight
262.73
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jérôme Lugrin, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833 (6) :1498-510|[2]Zainab Asad, et al. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo. Eur J Med Genet. 2020 Feb;63 (2) :103661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3

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