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Inotilone

CAT: 0804-HY-111172Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111172Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].
CAS Number
906366-79-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP; NF-κB
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/inotilone.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(OC(C)=C1)=C/C2=CC=C(O)C(O)=C2
Molecular Formula
C12H10O4
Molecular Weight
218.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. Sci Rep. 2019 Feb 20;9 (1) :2344.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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