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Methapyrilene

CAT: 0804-HY-111130-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111130-01Size:5 mg
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Description
Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
CAS Number
91-80-5
UNSPSC
12352005
Hazard Statement
H301
Target
Histamine Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/methapyrilene.html
Purity
99.66
Solubility
10 mM in DMSO
Smiles
CN(C)CCN(C1=NC=CC=C1)CC2=CC=CS2
Molecular Formula
C14H19N3S
Molecular Weight
261.39
Precautions
H301
References & Citations
[1]Volodymyr Tryndyak, et al. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223.|[2]Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5 (7) :1586-60
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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