DPC423

CAT: 0804-HY-11090ASize: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-11090ASize:1 Each

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Description

DPC423 is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis[1][2].

CAS Number

292135-59-2

UNSPSC

12352005

Target

Factor Xa; Kallikrein; Ser/Thr Protease; Thrombin

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dpc423.html

Solubility

10 mM in DMSO

Smiles

NCC1=CC(N2C(C(NC3=CC=C(C4=CC=CC=C4S(=O)(C)=O)C=C3F)=O)=CC(C(F)(F)F)=N2)=CC=C1.Cl

Molecular Formula

C25H21ClF4N4O3S

Molecular Weight

568.97

References & Citations

[1]D J Pinto, et al. Discovery of 1-[3- (aminomethyl) phenyl]-N-3-fluoro-2'- (methylsulfonyl) -[1,1'-biphenyl]-4-yl]-3- (trifluoromethyl) -1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2001 Feb 15;44 (4) :566-78. |[2]Wong PC, et al. Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits. J Pharmacol Exp Ther. 2002 Dec;303 (3) :993-1000.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

DPC423

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