DBM 1285 (dihydrochloride)

DBM 1285 (dihydrochloride)

• CAS Number: 1782532-29-9
• UNSPSC Description: DBM 1285 dihydrochloride is an orally active TNF-α production inhibitor with anti-inflammatory effects. DBM 1285 dihydrochloride inhibits Lipopolysaccharide (LPS)-induced TNF-α secretion in various cells of macrophage/monocyte lineage[1].
• Target Antigen: TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/dbm-1285-dihydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=C(C2=C(SC(C3CCNCC3)=N2)C4=CC=NC(NC5CC5)=N4)C=C1.Cl.Cl
• Molecular Weight: 468.42
• References & Citations: [1]Jong Soon Kang, et al. DBM1285 suppresses tumor necrosis factor alpha production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J Pharmacol Exp Ther. 2010 Aug;334(2):657-64.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported