Mefloquine (hydrochloride)

Mefloquine (hydrochloride)

• CAS Number: 51773-92-3
• UNSPSC Description: Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].
• Target Antigen: Autophagy; Parasite; Potassium Channel; ROS Kinase; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy;Membrane Transporter/Ion Channel;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection; Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mefloquine-hydrochloride.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 2.86 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O[C@H]([C@]1([H])NCCCC1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32.[H]Cl
• Molecular Weight: 414.77
• References & Citations: [1]Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.|[2]Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545.|[3]Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403.|[4]Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched