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XAP044

CAT: 0804-HY-110146-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110146-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].
CAS Number
196928-50-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xap044.html
Purity
99.99
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C2=CC=C(O)C=C2OC=C1OC3=CC=C(I)C=C3
Molecular Formula
C15H9IO4
Molecular Weight
380.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Gee CE, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289 (16) :10975-10987.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
M27492-01XAP044
WHA92850-01MGlu7 Antagonist, XAP044

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