MRS 1477

• Description :

  MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].

• CAS Number :

  [212200-21-0]

• UNSPSC :

  12352005

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mrs-1477.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCOC(C1=C(C2=CC=CC=C2)NC(C)=C(C(SCCOC)=O)C1CC)=O

• Molecular Formula :

  C21H27NO4S

• Molecular Weight :

  389.51

• References & Citations :

  [1]Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12 (6) :e0179950.|[2]Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340 (1) :152-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported