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Edaglitazone

CAT: 0804-HY-110118Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110118Size:1 mg
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Description
Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity[1][2][3].
CAS Number
213411-83-7
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/edaglitazone.html
Purity
99.58
Solubility
DMSO : 30 mg/mL (ultrasonic)
Smiles
CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C4=C3C=CS4)CC(S5)C(NC5=O)=O
Molecular Formula
C24H20N2O4S2
Molecular Weight
464.56
References & Citations
[1]Dietz M, et, al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7 (6) :1101-11. |[2]Fürnsinn C, et, al. Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br J Pharmacol. 1999 Nov;128 (6) :1141-8.|[3]Muñoz-Gutiérrez C, et, al. Study of the interactions between Edaglitazone and Ciglitazone with PPARγ and their antiplatelet profile. Life Sci. 2017 Oct 1;186:59-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ

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BA4465-1Edaglitazone

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