(R)-Gyramide A (hydrochloride)

(R)-Gyramide A (hydrochloride)

• CAS Number: 1793050-70-0
• UNSPSC Description: (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/r-gyramide-a-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl
• Molecular Weight: 442.98
• References & Citations: [1]Foss MH, et al. N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors. ACS Med Chem Lett. 2011 Apr 14;2(4):289-292.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported