(R)-Gyramide A (hydrochloride)

• UNSPSC Description:

  (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/r-gyramide-a-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl

• Molecular Weight:

  442.98

• References & Citations:

  [1]Foss MH, et al. N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors. ACS Med Chem Lett. 2011 Apr 14;2(4):289-292.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1793050-70-0