Trazpiroben

• Description :

  Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis[1].

• CAS Number :

  [1352993-39-5]

• Product Name Alternative :

  TAK-906

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/trazpiroben.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C1=CC=CC(CN2CN(C3CCCCC3)C4(CCN(CCCC(C5=CC=CC=C5)=O)CC4)C2=O)=C1

• Molecular Formula :

  C31H39N3O4

• Molecular Weight :

  517.66

• References & Citations :

  [1]Kuo B, Scimia C, Dukes G, Zhang W, Gupta S, Chen C, Chuang E, Camilleri M. Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis. Aliment Pharmacol Ther. 2021 Aug;54 (3) :267-280.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2