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Pecavaptan

CAT: 0804-HY-109133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109133Size:1 Each
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Description
Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively) . Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].
CAS Number
1914998-56-3
Product Name Alternative
BAY 1753011
UNSPSC
12352005
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pecavaptan.html
Solubility
10 mM in DMSO
Smiles
O[C@H](C(F)(F)F)CN1C(C2=CC=C(Cl)C=C2)=NN(CC3=NN(C4=CC(Cl)=CC=C4)C([C@@H](O)C)=N3)C1=O
Molecular Formula
C22H19Cl2F3N6O3
Molecular Weight
543.33
References & Citations
[1]Mondritzki T, et al. Cardiac output improvement by pecavaptan: a novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure. Eur J Heart Fail. 2021 May;23 (5) :743-750.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
V1a Receptor ; V2 Receptor

Alternative Products

CatalogName
GTR19209932-01Pecavaptan

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