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Adafosbuvir

CAT: 0804-HY-109047Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109047Size:1 Each
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Description
Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase[1].
CAS Number
1613589-09-5
Product Name Alternative
AL-335
UNSPSC
12352005
Target
DNA/RNA Synthesis; HCV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/adafosbuvir.html
Solubility
10 mM in DMSO
Smiles
C[C@@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@@](COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)(F)[C@H]1O)O
Molecular Formula
C22H29FN3O10P
Molecular Weight
545.45
References & Citations
[1]Tetsuo Takehara, et al. JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study. J Gastroenterol. 2020 Jun;55 (6) :640-652.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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MBS5776289Adafosbuvir
GTR19211853-01Adafosbuvir PM

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