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Mocravimod

CAT: 0804-HY-109038-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109038-01Size:5 mg
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Description
Mocravimod is an orally active sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod retains T cell effector function. Mocravimod can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) [1][2][3][4].
CAS Number
509092-16-4
Product Name Alternative
KRP-203 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; GSK-3; JAK; LPL Receptor; Reactive Oxygen Species (ROS) ; STAT
Type
Reference compound
Related Pathways
Epigenetics; GPCR/G Protein; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mocravimod.html
Purity
98.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCC(CCC1=CC=C(SC2=CC=CC(OCC3=CC=CC=C3)=C2)C=C1Cl)(N)CO
Molecular Formula
C24H26ClNO3S
Molecular Weight
443.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Simone Dertschnig, et al. Mocravimod, a Selective Sphingosine-1-Phosphate Receptor Modulator, in Allogeneic Hematopoietic Stem Cell Transplantation for Malignancy. Transplant Cell Ther. 2023 Jan;29 (1) :41.e1-41.e9. |[2]Dertschnig S, et al. Mocravimod, a Selective Sphingosine-1-Phosphate Receptor Modulator, in Allogeneic Hematopoietic Stem Cell Transplantation for Malignancy. Transplant Cell Ther. 2023 Jan;29 (1) :41.e1-41.e9.|[3]Suzuki et al. PS11.7: Mocravimod, a novel immunosuppressant, not only suppresses immune rejection but also promotes engraftment of intraportally transplanted islets by its anti-inflammatory and anti-coagulant effects.|[4]Potì F, et al. Mocravimod, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33 (7) :1505-12.|[5]Wu N, et al. The novel sphingosine-1-phosphate receptor modulator Mocravimod prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways. Cell Biol Toxicol. 2025 Nov 27;41 (1) :159.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
GSK-3β; JAK2; S1PR1; STAT3

Alternative Products

CatalogName
MBS5777777Mocravimod
T12086-01Mocravimod hydrochloride

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