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Valnivudine

CAT: 0804-HY-109016Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109016Size:1 Each
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Description
Valnivudine (FV-100 free base), a proagent of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV) . Valnivudine is rapidly and extensively converted to CF-1743 in vivo[1][2].
CAS Number
956483-02-6
Product Name Alternative
FV-100 (free base)
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/valnivudine.html
Purity
98.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N=C2C(C=C(C3=CC=C(C=C3)CCCCC)O2)=CN1[C@]4([H])O[C@@H]([C@H](C4)O)COC([C@@H](N)C(C)C)=O
Molecular Formula
C27H35N3O6
Molecular Weight
497.58
References & Citations
[1]Nathan B Price, et al. Progress in the development of new therapies for herpesvirus infections. Curr Opin Virol. 2011 Dec;1 (6) :548-54.|[2]Helen S Pentikis, et al. Pharmacokinetics and safety of FV-100, a novel oral anti-herpes zoster nucleoside analogue, administered in single and multiple doses to healthy young adult and elderly adult volunteers. Antimicrob Agents Chemother. 2011 Jun;55 (6) :2847-54.|[3]C McGuigan, et al. Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. J Med Chem. 2000 Dec 28;43 (26) :4993-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
MBS133300Valnivudine
FV180234-01Valnivudine hydrochloride

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