Oncaspar

CAT: 0804-HY-108860Size: 5 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-108860Size:5 mL

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Description

Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway[1].

CAS Number

130167-69-0

Product Name Alternative

PEG-L-asparaginase; Pegasparaginase

UNSPSC

12352203

Target

FGFR; Interleukin Related

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oncaspar.html

Purity

99.9

Solubility

10 mM in DMSO

Smiles

[Oncaspar]

References & Citations

[1]Young-A Heo, et al. Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.Drugs. 2019 May;79 (7) :767-777.|[2]He J, et al., Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis. Toxicol Appl Pharmacol. 2024 Apr;485:116920.

Shipping Conditions

Isolate blue ice and the product with bubble pack to avoid direct contact

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

Launched

Oncaspar

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