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Rasburicase

CAT: 0804-HY-108844Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108844Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout[1][2][3].
CAS Number
134774-45-1
UNSPSC
12352211
Hazard Statement
H317, H334
Target
Xanthine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/rasburicase.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
[Rasburicase]
Precautions
H317, H334
References & Citations
[1]Cammalleri L, et al. Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. Int J Med Sci. 2007 Mar 2;4 (2) :83-93.|[2]Xu H, et al. High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells. AAPS J. 2020 May 27;22 (4) :80.|[3]Kono H, et al. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest. 2010 Jun;120 (6) :1939-49.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Reference compound1
Clinical Information
Launched

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